• Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression 

      Pedersen, Hege Lynum; Horvei, Kjersti Daae; Thiyagarajan, Dhivya; Norby, Gudrun; Seredkina, Natalya; Moroni, Gabriella; Eilertsen, Gro Østli; Holdaas, Hallvard; Strøm, Erik Heyerdahl; Bakland, Gunnstein; Meroni, Pier Luigi; Rekvig, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-21)
      Renal DNase I is lost in advanced stages of lupus nephritis. Here, we determined if loss of renal DNase I reflects a concurrent loss of urinary DNase I, and whether absence of urinary DNase I predicts disease progression. Mouse and human DNase I protein and DNase I endonuclease activity levels were determined by western blot, gel, and radial activity assays at different stages of the murine and human ...
    • One-year protocol biopsies from ABO-incompatible renal allografts compared with a matched cohort of ABO-compatible allografts 

      Dörje, Christina; Mjøen, Geir; Strøm, Erik Heyerdahl; Holdaas, Hallvard; Jenssen, Trond Geir; Øyen, Ole; Akkøk, Cigdem Ahaein; Småstuen, Milada C; Midtvedt, Karsten; Reisæter, Anna Varberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-21)
      Abstract: Introduction: Early acute antibody-mediated rejection (ABMR) occurs more frequently in ABO-incompatible (ABOi) than in ABO-compatible (ABOc) kidney transplantation. This could lead to increased inflammation/scarring in the ABOi grafts. Protocol biopsy data in ABOi kidney recipients are scarce.<p> <p>Methods: A single-center retrospective matched cohort study was conducted. Eighty ...